Computer-based design of an HLA-haplotype and HIV-clade independent cytotoxic T-lymphocyte assay for monitoring HIV-specific immunity.
Identifieur interne : 003337 ( Main/Exploration ); précédent : 003336; suivant : 003338Computer-based design of an HLA-haplotype and HIV-clade independent cytotoxic T-lymphocyte assay for monitoring HIV-specific immunity.
Auteurs : Massimo Amicosante [Italie] ; Cristiana Gioia ; Carla Montesano ; Rita Casetti ; Simone Topino ; Gianpiero D'Offizi ; Giulia Cappelli ; Giuseppe Ippolito ; Vittorio Colizzi ; Fabrizio Poccia ; Leopoldo P. PucilloSource :
- Molecular medicine (Cambridge, Mass.) [ 1076-1551 ] ; 2002.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antigènes HLA (immunologie), Données de séquences moléculaires, Dosage biologique, Femelle, Humains, Interféron gamma (métabolisme), Lymphocytes T cytotoxiques (immunologie), Lymphocytes T cytotoxiques (métabolisme), Mâle, Peptides (immunologie), Produits du gène gag (immunologie), Séquence d'acides aminés, VIH (Virus de l'Immunodéficience Humaine) (immunologie).
- MESH :
- immunologie : Antigènes HLA, Lymphocytes T cytotoxiques, Peptides, Produits du gène gag, VIH (Virus de l'Immunodéficience Humaine).
- métabolisme : Interféron gamma, Lymphocytes T cytotoxiques.
- Adulte, Adulte d'âge moyen, Données de séquences moléculaires, Dosage biologique, Femelle, Humains, Mâle, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Adult, Amino Acid Sequence, Biological Assay, Female, Gene Products, gag (immunology), HIV (immunology), HLA Antigens (immunology), Humans, Interferon-gamma (metabolism), Male, Middle Aged, Molecular Sequence Data, Peptides (immunology), T-Lymphocytes, Cytotoxic (immunology), T-Lymphocytes, Cytotoxic (metabolism).
- MESH :
- chemical , immunology : Gene Products, gag, HLA Antigens, Peptides.
- immunology : HIV, T-Lymphocytes, Cytotoxic.
- chemical , metabolism : Interferon-gamma, T-Lymphocytes, Cytotoxic.
- Adult, Amino Acid Sequence, Biological Assay, Female, Humans, Male, Middle Aged, Molecular Sequence Data.
Abstract
Human immunodeficiency virus (HIV)- specific CD8-positive cytotoxic T-lymphocytes (CTL) play a key role in controlling HIV infection. Monitoring CTL response could be clinically relevant during structured therapy interruption (STI), HIV exposure, and vaccine trials. However, HLA patients' restriction and HIV variability limited the development of a CTL assay with broad specificity.
PubMed: 12606814
Affiliations:
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Le document en format XML
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Pucillo</name></author></analytic><series><title level="j">Molecular medicine (Cambridge, Mass.)</title><idno type="ISSN">1076-1551</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Amino Acid Sequence</term><term>Biological Assay</term><term>Female</term><term>Gene Products, gag (immunology)</term><term>HIV (immunology)</term><term>HLA Antigens (immunology)</term><term>Humans</term><term>Interferon-gamma (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Molecular Sequence Data</term><term>Peptides (immunology)</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>T-Lymphocytes, Cytotoxic (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes HLA (immunologie)</term><term>Données de séquences moléculaires</term><term>Dosage biologique</term><term>Femelle</term><term>Humains</term><term>Interféron gamma (métabolisme)</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Lymphocytes T cytotoxiques (métabolisme)</term><term>Mâle</term><term>Peptides (immunologie)</term><term>Produits du gène gag (immunologie)</term><term>Séquence d'acides aminés</term><term>VIH (Virus de l'Immunodéficience Humaine) (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Gene Products, gag</term><term>HLA Antigens</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes HLA</term><term>Lymphocytes T cytotoxiques</term><term>Peptides</term><term>Produits du gène gag</term><term>VIH (Virus de l'Immunodéficience Humaine)</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interferon-gamma</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Interféron gamma</term><term>Lymphocytes T cytotoxiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Amino Acid Sequence</term><term>Biological Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Données de séquences moléculaires</term><term>Dosage biologique</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human immunodeficiency virus (HIV)- specific CD8-positive cytotoxic T-lymphocytes (CTL) play a key role in controlling HIV infection. Monitoring CTL response could be clinically relevant during structured therapy interruption (STI), HIV exposure, and vaccine trials. However, HLA patients' restriction and HIV variability limited the development of a CTL assay with broad specificity.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><noCountry><name sortKey="Cappelli, Giulia" sort="Cappelli, Giulia" uniqKey="Cappelli G" first="Giulia" last="Cappelli">Giulia Cappelli</name><name sortKey="Casetti, Rita" sort="Casetti, Rita" uniqKey="Casetti R" first="Rita" last="Casetti">Rita Casetti</name><name sortKey="Colizzi, Vittorio" sort="Colizzi, Vittorio" uniqKey="Colizzi V" first="Vittorio" last="Colizzi">Vittorio Colizzi</name><name sortKey="D Offizi, Gianpiero" sort="D Offizi, Gianpiero" uniqKey="D Offizi G" first="Gianpiero" last="D'Offizi">Gianpiero D'Offizi</name><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><name sortKey="Montesano, Carla" sort="Montesano, Carla" uniqKey="Montesano C" first="Carla" last="Montesano">Carla Montesano</name><name sortKey="Poccia, Fabrizio" sort="Poccia, Fabrizio" uniqKey="Poccia F" first="Fabrizio" last="Poccia">Fabrizio Poccia</name><name sortKey="Pucillo, Leopoldo P" sort="Pucillo, Leopoldo P" uniqKey="Pucillo L" first="Leopoldo P" last="Pucillo">Leopoldo P. Pucillo</name><name sortKey="Topino, Simone" sort="Topino, Simone" uniqKey="Topino S" first="Simone" last="Topino">Simone Topino</name></noCountry><country name="Italie"><region name="Latium"><name sortKey="Amicosante, Massimo" sort="Amicosante, Massimo" uniqKey="Amicosante M" first="Massimo" last="Amicosante">Massimo Amicosante</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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